Direct monitoring of immediate release of Zn from zinc doped bioactive glass

Zinc-doped bioactive glass prepared by conventional melting was tested in simulated body fluid (SBF) to quantitatively determine zinc ion release at the early stage of dissolution glass. The analysis leaching solution performed a flow-through arrangement, with reaction cell connected directly nebulizer ICP OES. Possible formation silicate and phosphate as alteration products precipitating from SBF along hydroxyapatite evaluated using PHREEQC modeling code. Direct monitoring first 10-min interval contact contributed determination immediate quantity leached confirmed burst material, maximum after ∼4.5 min SBF.